Saponins are responsible for the anti-obesogenic activity of Acacia concinna

Acacia concinna (Willd.) DC. is a medicinal plant sourced mainly from Southeast Asia. The pods of (A. concinna) are potential candidate to treat or prevent obesity; however, these attributes have not been examined in detail. In this study, the anti-obesogenic compounds A. were investigated. Chromatographic separation pod extract guided by pancreatic lipase inhibitory activity led isolation saponins. Decomposition analysis saponins revealed their chemical composition be acacic acid, monoterpenes, and five types sugars (glucose, xylose, rhamnose, quinovose, arabinose). predicted structures decomposition confirmed LC–MS analysis, showing that mixture various derivatives monoterpenes sugar units. These inhibited strongly with an IC50 7.9 μg/mL, reduced lipid accumulation 3T3-L1 adipocytes at 6.3 μg/mL. also enhanced lipolysis 3.1 μg/mL mediating protein kinase A extracellular signal-regulated pathways, suggesting mechanism partly responsible for observed reduction content adipocytes. results underline as source candidates future treatment prevention obesity.